ProGP135 (37-kDa protein)

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ProGP ID ProGP135 (37-kDa protein)
Validation Status Uncharacterized
Organism Information
Organism NameActinobacillus actinomycetemcomitans Y4 (serotype b)
Domain Bacteria
Classification Family: Pasteurellaceae
Order: Pasteurellales
Class: Gammaproteobacteria
Division or phylum: "Proteobacteria"
Taxonomic ID (NCBI) 714
Genome Information
GenBank NZ_CP016553.1.
EMBL AB011405
Protein Information
Protein Name37-kDa protein
Subcellular LocationExtracellular
Function Plays a role in A. actinomycetemcomitans-associated periodontitis, as antigen inducing the release of inflammatory cytokines which are associated with alveolar bone loss. The IL-6-inducing activity was higher than that of LPS.
Glycosylation Status
Technique(s) used for Glycosylation DetectionImmunoblotting using anti glycan antibodies.
Literature
Year of Identification1997
Year of Identification Month Wise1997.9
ReferenceTani, Y., Tani, M. and Kato, I. (1997) Extracellular 37-kDa antigenic protein from Actinobacillus actinomycetemcomitans induces TNF-alpha, IL-1 beta, and IL-6 in murine macrophages. J Dent Res, 76, 1538-1547. [PubMed: 9294487]
Author Tani, Y., Tani, M. Kato, I.
Research GroupDepartment of Periodontology, Nagasaki University School of Dentistry, Japan.
Corresponding Author Kato, I.
ContactDepartment of Periodontology, Nagasaki University School of Dentistry, Japan.