ProGT11 (TibC)
| ProGT ID | ProGT11 (TibC) |
| Organism Information | |
| Organism Name | Escherichia coli ETEC |
| Clinical Implication | Pathogenic |
| Domain | Bacteria |
| Classification | Phylum : Proteobacteria Class : GammaProteobacteria Orders : Enterobacterales Family : Enteerobacteriaceae Genus : Escherichia Species : coli Subspecies : ETEC |
| Taxonomic ID (NCBI) | 316401 |
| Genome Information | |
| Gene Bank | AF131891 |
| EMBL | AF131891 |
| Gene Information | |
| Gene Name | tibC |
| Protein information | |
| Protein Name | TibC |
| UniProtKB/ SwissProt ID | Q9S4K6 |
| NCBI Ref Seq | WP_000105682.1 |
| UniProtKB Sequence | >sp|Q9S4K6|TIBC_ECOH1 Glycosyltransferase TibC OS=Escherichia coli O78:H11 (strain H10407 / ETEC) GN=tibC PE=1 SV=1 MSTLKNTFFITPPDTPTQAGPENIFYDFNDGARVLLPEGKWHVRLLDADSENILFCCDVD KGWVTSSKKYFVRFRIQVFRQGEETPLLDETLKLKDRPVLISFPTGTLGDLLGWFPYAER FQSLHKCRLECTMSQDIIDLLAPQYPQIQFSTPDKPRTVAPYATYRVGLYFGGDTNNQPV DFRKVGFHRSAGYILGVDPREAPVRLDLSAPRVIQEPYVCIATQSTCQAKYWNNGTGWSE VIAHLKSLGYRVMCIDRDAHYGQGFVWNHIPWGAEDFTGKLPLQERVNLLRHASFFIGLP SGLSWLAWATRIPVVLISGFSLPNSEFYTPWRVFNSHGCYGCWDDTSLNFDHHDFLWCPR HKNTDRQFECTRLITGAQVNGVINKLHRSLTEQGVEATLKKGVSNE |
| EMBL CDS | AAD46996.1 |
| Sequence length | 406 AA |
| Subcellular Location | Cytoplasm |
| Function in Native Organism | 1) TibC is the protein transfer the heptose sugar to the protein TibA. |
| Glycosyltransferase Information | |
| Glycosylation Type | O- (Ser/Thr) linked |
| CAZY Family | GTNC |
| EC Number (BRENDA) | 2.4.99 |
| Mechanism of Glycan Transfer | Sequential |
| Acceptor specificity Sequon_1 | NGGKTTATTVNSSGSQNVG |
| Donor Type | ADP-Heptose |
| Donor Specificity | Nucleotide activated sugars |
| Glycan Information | |
| Glycan transferred | Monosaccharide (Heptose) |
| Method of Glycan Indentification | DIG glycan detection |
| Experimental_strategies | In vivo |
| Acceptor Subtrate Information | |
| Acceptor Substrate name | TibA |
| ProGPdb ID | ProGP176 |
| Acceptor Substrate name | AIDA-I |
| ProGPdb ID | ProGP201 |
| Litrature | |
| Year Of Validation | 2002 |
| Reference | Moormann, C., Benz, I. and Schmidt, M.A., 2002. Functional substitution of the TibC protein of enterotoxigenic Escherichia coli strains for the autotransporter adhesin heptosyltransferase of the AIDA system. Infection and immunity, 70(5), pp.2264-2270. |
| Corresponding Author | Institute of Infectiology, Center for Molecular Biology of Inflammation, West of Wilhelms-University of Münster, D-48149 Münster, Germany. |
| Reference | Charbonneau, M.È., Côté, J.P., Haurat, M.F., Reiz, B., Crépin, S., Berthiaume, F., Dozois, C.M., Feldman, M.F. and Mourez, M., 2012. A structural motif is the recognition site for a new family of bacterial protein O?glycosyltransferases. Molecular microbiology, 83(5), pp.894-907. |
| Corresponding Author | Canada Research Chair on Bacterial Animal Diseases, University of Montreal, Faculty of Veterinary Medicine St-Hyacinthe, 3200 Sicotte, St-Hyacinthe, Quebec, Canada. |