ProGP170

Home -> ProGPdb -> Search ProGP -> Display data

ProGP ID ProGP170
Validation Status Uncharacterized
Organism Information
Organism NameClostridium difficile C253
Domain Bacteria
Classification Family: Clostridiaceae
Order: Clostridiales
Class: Clostridia
Division or phylum: "Firmicutes"
Taxonomic ID (NCBI) 1496
Genome Sequence(s)
GenBank GU048823
EMBL GU048823
Organism Additional Information Clostridium difficile is a gram-positive, anaerobic, spore-forming bacterium that produces TcdA and TcdB toxins causing severe tissue damage. It ia an opportunistic pathogen that is the major cause of antibiotic-associated diarrhoea and pseudomembranous colitis in humans. C. dificile infection can also result in abdominal pain, inflammation, and ulceration of the lining of the intestinal wall.
Protein Information
Protein NameSurface layer glycoproteins
Subcellular LocationSurface
Function Two glycoproteins P36 and P47 are the components of the S-layer.
Glycosylation Status
Glycosite Sequence Logo
Technique(s) used for Glycosylation DetectionDIG glycan/protein double labeling kit and thymol staining method.
Literature
Year of Identification1999
Year of Identification Month Wise1999.5
ReferenceCalabi, E., Ward, S., Wren, B., Paxton, T., Panico, M., Morris, H., Dell, A., Dougan, G. and Fairweather, N. (200Molecular characterization of the surface layer proteins from Clostridium difficile. Mol Microbiol, 40, 1187-1199. [PubMed: 11401722]
AuthorCalabi E, Ward S, Wren B, Paxton T, Panico M, Morris H, Dell A, Dougan G, Fairweather N.
Research GroupDepartment of Biology and Biochemistry, Imperial College, South Kensington, London SW7 2AY, UK.
Corresponding Author Fairweather N.
ContactDepartment of Biology and Biochemistry, Imperial College, South Kensington, London SW7 2AY, UK.
ReferenceKarjalainen, T., Waligora-Dupriet, A.J., Cerquetti, M., Spigaglia, P., Maggioni, A., Mauri, P. and Mastrantonio, P. (2001) Molecular and genomic analysis of genes encoding surface-anchored proteins from Clostridium difficile. Infect Immun, 69, 3442-3446. [PubMed: 11292772]
AuthorKarjalainen, T., Waligora-Dupriet, A.J., Cerquetti, M., Spigaglia, P., Maggioni, A., Mauri, P. Mastrantonio, P.
Research GroupDepartment of Microbiology, Faculty of Pharmacy, University of Paris-Sud, 92296 Châtenay-Malabry Cedex, France
Corresponding Author Mastrantonio, P.
ContactDepartment of Microbiology, Faculty of Pharmacy, University of Paris-Sud, 92296 Châtenay-Malabry Cedex, France
ReferenceCerquetti, M., Molinari, A., Sebastianelli, A., Diociaiuti, M., Petruzzelli, R., Capo, C. and Mastrantonio, P. (2000) Characterization of surface layer proteins from different Clostridium difficile clinical isolates. Microb Pathog, 28, 363-372.
AuthorCerquetti, M., Molinari, A., Sebastianelli, A., Diociaiuti, M., Petruzzelli, R., Capo, C. Mastrantonio, P.
Research GroupDepartment of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, viale Regina Elena 299, Rome, 00161, Italy.
Corresponding Author Mastrantonio, P.
ContactDepartment of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, viale Regina Elena 299, Rome, 00161, Italy.
ReferenceMauri, P.L., Pietta, P.G., Maggioni, A., Cerquetti, M., Sebastianelli, A. and Mastrantonio, P. (1999) Characterization of surface layer proteins from Clostridium difficile by liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom, 13, 695-703. [PubMed: 10343411]
AuthorMauri, P.L., Pietta, P.G., Maggioni, A., Cerquetti, M., Sebastianelli, A. and Mastrantonio, P
Research GroupInstitute of Advanced Biomedical Technologies / CNR, Segrate-Milano, Italy.
Corresponding Author Mastrantonio, P
ContactInstitute of Advanced Biomedical Technologies / CNR, Segrate-Milano, Italy.