ProGP214 (Flagellin B)

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ProGP ID ProGP214 (Flagellin B)
Validation Status Uncharacterized
Organism Information
Organism NameHelicobacter (Campylobacter) pylori 1061/J99
Domain Bacteria
Classification Phylum : Proteobacteria
Class : Epsilonproteobacteria
Orders : Campylobacterales
Family : Helicobacteraceae
Genus : Helicobacter
Species : pylori
Strain : 1061/J99
Taxonomic ID (NCBI) 85963
Genome Information
GenBank AE001439.1
EMBL AE001439
Organism Additional Information Helicobacter pylori is a Gram-negative, microaerophilic, human gastric pathogen classified by WHO as a Type 1 carcinogen. Its lipopolysaccharide (LPS) O-antigen is responsible for its virulence. Lewis antigens on its O-polysaccharides mimic glycan structures on human cells and interact with the C-type lectin DC-SIGN on dendritic cells, thereby down-regulating an inflammatory response. It also causes chronic type B gastritis (a prerequisite for duodenal ulcers) and is linked with mucosa-associated lymphoid tissue (MALT) and with B-cell MALT lymphomas.
Gene Information
Gene NameflaB ( jhp_0107)
NCBI Gene ID 889505
GenBank Gene Sequence NC_000921.1
Protein Information
Protein NameFlagellin B
UniProtKB/SwissProt ID Q9ZMV8
NCBI RefSeq WP_000010021.1
EMBL-CDSAAD05686.1
UniProtKB Sequence >sp|Q9ZMV8|FLAB_HELPJ Flagellin B OS=Helicobacter pylori J99 GN=flaB PE=3 SV=3 MSFRINTNIAALTSHAVGVQNNRDLSSSLEKLSSGLRINKAADDSSGMAIADSLRSQSAN LGQAIRNANDAIGMVQTADKAMDEQIKILDTIKTKAVQAAQDGQTLESRRALQSDIQRLL EELDNIANTTSFNGQQMLSGSFSNKEFQIGAYSNTTVKASIGSTSSDKIGHVRMETSSFS GEGMLASAAAQNLTEVGLNFKQVNGVNDYKIETVRISTSAGTGIGALSEIINRFSNTLGV RASYNVMATGGTPVQSGTVRELTINGVEIGTVNDVHKNDADGRLTNAINSVKDRTGVEAS LDIQGRINLHSIDGRAISVHAASASGQVFGGGNFAGISGTQHAVIGRLTLTRTDARDIIV SGVNFSHVGFHSAQGVAEYTVNLRAVRGIFDANVASAAGANANGAQAETNSQGIGAGVTS LKGAMIVMDMADSARTQLDKIRSDMGSVQMELVTTINNISVTQVNVKAAESQIRDVDFAE ESANFSKYNILAQSGSFAMAQANAVQQNVLRLLQ
Sequence length 514 AA
Subcellular LocationSecreted
Function Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Important for motility and virulence.
Glycosylation Status
Glycosylation Type O- (Ser/Thr) linked
Technique(s) used for Glycosylation DetectionImmunoblotting using antiglycan antiserum.
Glycan Information
Glycan Annotation Pseudaminic acid (Pse5Ac7Ac, 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-L-manno-nonulosonic acid). O-linkage Ser/Thr at 10 sites.
BCSDB ID 4618
GlyTouCan G75457NU
Literature
Year of Identification2002
Year of Identification Month Wise2002.5
ReferenceSchoenhofen, I.C., Lunin, V.V., Julien, J.P., Li, Y., Ajamian, E., Matte, A., Cygler, M., Brisson, J.R., Aubry, A., Logan, S.M. and Bhatia, S., 2006. Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in Helicobacter pylori. Journal of Biological Chemistry, 281(13), pp.8907-8916.
Corresponding Author N. Martin Young
ContactInstitute for Biological Sciences, National Research Council, Ottawa, Ontario K1A 0R6.
ReferenceSchirm, M., Soo, E.C., Aubry, A.J., Austin, J., Thibault, P. and Logan, S.M., 2003. Structural, genetic and functional characterization of the flagellin glycosylation process in Helicobacter pylori. Molecular microbiology, 48(6), pp.1579-1592.
Corresponding Author Susan M Logan
ContactInstitute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada.
ReferenceJosenhans, C., Vossebein, L., Friedrich, S. and Suerbaum, S., 2002. The neuA/flmD gene cluster of Helicobacter pylori is involved in flagellar biosynthesis and flagellin glycosylation. FEMS microbiology letters, 210(2), pp.165-172.
Corresponding Author Christine Josenhans
ContactInstitute for Hygiene and Microbiology at the University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany