ProGT138 (YGT)

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ProGT ID ProGT138 (YGT)
Organism Information
Organism NameYersinia mollaretii
Clinical ImplicationPathogenic
Classification Phylum : Proteobacteria
Class : GammaProteobacteria
Orders : Enterobacterales
Family : Yersiniaceae
Genus : Yersinia
Species : mollaretii
Taxonomic ID (NCBI)349967
Genome Information
Gene Information
Gene Nameygt
Protein information
Protein NameYGT 
Function in Native Organism It is glucosyltransferase and transfer N-acetylglucosaminylates Rab5 and Rab31 at Thr52 and Thr36, respectively
Additional InformationThe glycosylation of Rab5 and Rab31 inhibiting GTP hydrolysis.
Glycosyltransferase Information
Glycosylation TypeO- (Thr) linked 
CAZY FamilyGT44
Mechanism of Glycan TransferSequential
Donor SpecificityNucleotide activated sugars
Glycan Information
Method of Glycan IndentificationNanoLC-MS/MS analysis and Western Blotting
Experimental_strategiesIn vitro 
Acceptor Subtrate Information
Acceptor Substrate name Rab5
Acceptor Substrate name Rab31
Year Of Validation2020 
Reference Ost, G.S., Wirth, C., Bogdanovi?, X., Kao, W.C., Schorch, B., Aktories, P.J., Papatheodorou, P., Schwan, C., Schlosser, A., Jank, T. and Hunte, C., 2020. Inverse control of Rab proteins by Yersinia ADP-ribosyltransferase and glycosyltransferase related to clostridial glucosylating toxins. Science advances, 6(11), p.eaaz2094.

Corresponding AuthorInstitut für Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany