ProGP194 (PS4A (water soluble protein-polysaccharide))
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| ProGP ID | ProGP194 (PS4A (water soluble protein-polysaccharide)) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Mycobacterium vaccae |
| Domain | Bacteria |
| Classification | Phylum : Actinobacteria Class : Actinomycetia Orders : Corynebacteriales Family : Mycobacteriaceae Genus : Mycobacterium Species : vaccae |
| Taxonomic ID (NCBI) | 1810 |
| Genome Information | |
| GenBank | NZ_JH814686.1. |
| EMBL | ALQA01000006 |
| Protein Information | |
| Protein Name | PS4A (water soluble protein- polysaccharide) |
| Subcellular Location | Intracellular |
| Function | PS4A significantly decreased tumor incidence in vivo, produced activation of murine peritoneal macrophages. However, the antineoplastic activity was only attributable to the high molecular weight fraction of the protein-polysaccharide complex. The low molecular weight fraction had no antineoplastic activity in-vivo despite stimulation of TNF-α production in-vitro. In vitro experiments also demonstrated that although all PS4A components significantly increased TNF-α production by macrophages, the high molecular weight fraction stimulated more IL-1 production, indicating a better immunostimulating activity. |
| Literature | |
| Year of Identification | 2000 |
| Year of Identification Month Wise | 2000.06 |
| Reference | Tian, X.X., Li, A., Farrugia, I.V., Mo, X., Crich, D. and Groves, M.J., 2000. Isolation and identification of poly-α-(1→ 4)-linked 3-O-methyl-D-mannopyranose from a hot-water extract of Mycobacterium vaccae. Carbohydrate Research, 324(1), pp.38-44. |
| Corresponding Author | Michael J Groves |
| Contact | Institute for Tuberculosis Research (M/C 964), College of Pharmacy, University of Illinois at Chicago 60607, USA. |
| Reference | Tian, X.X., Li, A.F.E.N.G., Zhou, W.E.N.C.H.U.N., Farrugia, I.V. and Groves, M.J., 1999. Isolation and biological activities of an antineoplastic protein-polysaccharide complex (PS4A) obtained from Mycobacterium vaccae. Anticancer research, 19(1A), pp.237-243. |
| Corresponding Author | Michael J Groves |
| Contact | Institute for Tuberculosis Research (M/C 964), College of Pharmacy, University of Illinois at Chicago 60607, USA. |