ProGP33 (Streptococcal acid glycoprotein SAGP)

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ProGP ID ProGP33 (Streptococcal acid glycoprotein SAGP)
Validation Status Uncharacterized
Organism Information
Organism NameStreptococcus pyogenes strain Su
Domain Bacteria
Classification Phylum : Firmicutes
Class : Bacilli
Orders : Lactobacillales
Family : Streptococcaceae
Genus : Streptococcus
Species : pyogenes
Strain : Su
Taxonomic ID (NCBI) 1314
Genome Information
GenBank X55659
EMBL X55659
Gene Information
Gene NamearcA or sagP
Protein Information
Protein NameStreptococcal acid glycoprotein SAGP
UniProtKB/SwissProt ID P0C0B3
EMBL-CDSCAA39192.1
UniProtKB Sequence >sp|P0C0B3|ARCA_STRPY Arginine deiminase OS=Streptococcus pyogenes GN=arcA PE=1 SV=2 MTAQTPIHVYSEIGKLKKVLLHRPGKEIENLMPDYLERLLFDDIPFLEDAQKEHDAFAQA LRDEGIEVLYLETLAAESLVTPEIREAFIDEYLSEANIRGRATKKAIRELLMAIEDNQEL IEKTMAGVQKSELPEIPASEKGLTDLVESNYPFAIDPMPNLYFTRDPFATIGTGVSLNHM FSETRNRETLYGKYIFTHHPIYGGGKVPMVYDRNETTRIEGGDELVLSKDVLAVGISQRT DAASIEKLLVNIFKQNLGFKKVLAFEFANNRKFMHLDTVFTMVDYDKFTIHPEIEGDLRV YSVTYDNEELHIVEEKGDLAELLAANLGVEKVDLIRCGGDNLVAAGREQWNDGSNTLTIA PGVVVVYNRNTITNAILESKGLKLIKIHGSELVRGRGGPRCMSMPFEREDI
Sequence length 411 AA
Subcellular LocationIntracellular
Function Antitumour protein.
Literature
Year of Identification1985
Year of Identification Month Wise1985.1
ReferenceDegnan, B.A., Fontaine, M.C., Doebereiner, A.H., Lee, J.J., Mastroeni, P., Dougan, G., Goodacre, J.A. and Kehoe, M.A., 2000. Characterization of an isogenic mutant of Streptococcus pyogenes Manfredo lacking the ability to make streptococcal acid glycoprotein. Infection and Immunity, 68(5), pp.2441-2448.
Corresponding Author Degnan BA
ContactSchool of Clinical Medical Sciences (Rheumatology), Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom.
ReferenceDegnan, B.A., Palmer, J.M., Robson, T., Jones, C.E.D., Fischer, M., Glanville, M., Mellor, G.D., Diamond, A.G., Kehoe, M.A. and Goodacre, J.A., 1998. Inhibition of human peripheral blood mononuclear cell proliferation by Streptococcus pyogenes cell extract is associated with arginine deiminase activity. Infection and Immunity, 66(7), pp.3050-3058.
Corresponding Author J.A .Goodacre
ContactSchool of Clinical Medical Sciences (Rheumatology), Immunological and Virological Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, United Kingdom
ReferenceKanaoka, M., Negoro, T., Kawanaka, C., Agui, H. and Nabeshima, S., 1991. Streptococcal antitumor protein: expression in Escherichia coli cells and properties of the recombinant protein. Agricultural and biological chemistry, 55(3), pp.743-750.
Corresponding Author M Kanaoka
ContactTakarazuka Research Center, Sumitomo Chemical Co., Ltd., Hyogo, Japan.
ReferenceKANAOKA, M., FUKITA, Y., TAYA, K., KAWANAKA, C., NEGORO, T. and AGUI, H., 1987. Antitumor activity of streptococcal acid glycoprotein produced by Streptococcus pyogenes Su. Japanese Journal of Cancer Research GANN, 78(12), pp.1409-1414.
Corresponding Author Hideo Agui
ContactBiotechnology Laboratory, Takarazuka Research Center, Sumitomo Chemical Co. Ltd., Hyogo.