ProGP157 (HBHA (heparin-binding hemagglutinin))
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| ProGP ID | ProGP157 (HBHA (heparin-binding hemagglutinin)) |
| Validation Status | Uncharacterized |
| Organism Information | |
| Organism Name | Mycobacterium bovis BCG strain 1173P2 |
| Domain | Bacteria |
| Classification | Phylum : Actinobacteria Class : Actinomycetia Orders : Corynebacteriales Family : Mycobacteriaceae Genus : Mycobacterium Species : bovis Strain : BCG strain 1173P2 |
| Taxonomic ID (NCBI) | 410289 |
| Genome Information | |
| GenBank | AM408590.1 |
| EMBL | AM408590 |
| Organism Additional Information | Mycobacterium bovis is the etiologic agent of bovine tuberculosis. |
| Gene Information | |
| Gene Name | hbhA (BCG_0516) |
| NCBI Gene ID | 4696475 |
| GenBank Gene Sequence | NC_008769.1 |
| Protein Information | |
| Protein Name | HBHA (heparin-binding hemagglutinin) |
| UniProtKB/SwissProt ID | A1KFU9 |
| NCBI RefSeq | WP_003402339.1 |
| EMBL-CDS | CAL70501.1 |
| UniProtKB Sequence | >sp|A1KFU9|HBHA_MYCBP Heparin-binding hemagglutinin OS=Mycobacterium bovis (strain BCG / Pasteur 1173P2) GN=hbhA PE=1 SV=1 MAENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRTDTRSRVEESRARLTKL QEDLPEQLTELREKFTAEELRKAAEGYLEAATSRYNELVERGEAALERLRSQQSFEEVSA RAEGYVDQAVELTQEALGTVASQTRAVGERAAKLVGIELPKKAAPAKKAAPAKKAAPAKK AAAKKAPAKKAAAKKVTQK |
| Sequence length | 199 AA |
| Subcellular Location | Surface |
| Function | Mycobacterial heparin-binding hemagglutinin (HBHA) functions as an adhesin for epithelial cells and induces bacterial auto-aggregation. Glycosylation of HBHA may protect the protein from proteolytic degradation (crucial for its stabilty), important for HBHA-mediated hemagglutination and for certain immunologic properties of the protein. |
| Glycosylation Status | |
| Technique(s) used for Glycosylation Detection | Mass shift detected on SDS-polyacrylamide gel and carbohydrate content determination by GC/ mass spectrophotometry analysis |
| Literature | |
| Year of Identification | 1998 |
| Year of Identification Month Wise | 1998.08.07 |
| Reference | Menozzi, F.D., Bischoff, R., Fort, E., Brennan, M.J. and Locht, C., 1998. Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin. Proceedings of the National Academy of Sciences, 95(21), pp.12625-12630. |
| Corresponding Author | C Locht |
| Contact | Genetic and Molecular Microbiology Laboratory, National Institute of Health and Medical Research U447, Institut Pasteur de Lille, 1 rue Calmette, F-59019 Lille Cedex, France |