ProGP270 (BlaC)

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ProGP ID ProGP270 (BlaC)
Validation Status Uncharacterized
Organism Information
Organism NameMycobacterium tuberculosis
Domain Bacteria
Classification Phylum : Actinobacteria
Class : Actinomycetia
Orders : Corynebacteriales
Family : Mycobacteriaceae
Genus : Mycobacterium
Species : tuberculosis
Taxonomic ID (NCBI) 1773
Genome Information
GenBank AL123456.3
EMBL BX842578
Organism Additional Information It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens.
Gene Information
Gene NameblaC (Rv2068c)
NCBI Gene ID 888742
GenBank Gene Sequence NC_000962.3
Protein Information
Protein NameBlaC
UniProtKB/SwissProt ID P9WKD3
NCBI RefSeq WP_003410677.1
EMBL-CDSAL123456.3
UniProtKB Sequence >sp|P9WKD3|BLAC_MYCTU Beta-lactamase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=blaC PE=1 SV=1 MRNRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLADRFAELERRYDARLG VYVPATGTTAAIEYRADERFAFCSTFKAPLVAAVLHQNPLTHLDKLITYTSDDIRSISPV AQQHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDA EEPELNRDPPGDERDTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAG FPADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRAGGGYDAEPREALLAEAAT CVAGVLA
Sequence length 307 AA
Subcellular LocationMembrane
Function Beta-lactamase (EC=3.5.2.6).
Protein Structure
PDB ID 2GDN, 3CG5, 3IQA, 3M6B, 3M6H, 3N8S, 3NY4
Glycosylation Status
ProGP Web Logo
Technique(s) used for Glycosylation DetectionConcanavalin A (ConA) binding
Literature
Year of Identification2009
Year of Identification Month Wise2009.2
ReferenceGonzález-Zamorano, M., Mendoza-Hernández, G., Xolalpa, W., Parada, C., Vallecillo, A.J., Bigi, F. and Espitia, C., 2009. Mycobacterium tuberculosis glycoproteomics based on ConA-lectin affinity capture of mannosylated proteins. Journal of proteome research, 8(2), pp.721-733.
Corresponding Author Clara Espitia
ContactImmunology Department, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico.