ProGP452 (Probable conserved proline rich membrane protein (MT2222))
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ProGP ID | ProGP452 (Probable conserved proline rich membrane protein (MT2222)) |
Validation Status | Characterized |
Organism Information | |
Organism Name | Mycobacterium tuberculosis H37Rv |
Domain | Bacteria |
Classification | Phylum : Actinobacteria Class : Actinomycetia Orders : Corynebacteriales Family : Mycobacteriaceae Genus : Mycobacterium Species : tuberculosis Strain : H37Rv |
Taxonomic ID (NCBI) | 83332 |
Genome Information | |
GenBank | NC_000962.3 |
EMBL | CP009480 |
Organism Additional Information | It is the causative agent of human tuberculosis. The pathogenesis is influenced by its lipoglycans and glycolipids (having a wide range of immunomodulatory activities), and a variety of its virulence factors and antigens. |
Gene Information | |
Gene Name | Rv2164c |
NCBI Gene ID | 887217 |
GenBank Gene Sequence | NC_000962.3 |
Protein Information | |
Protein Name | Probable conserved proline rich membrane protein (MT2222) |
UniProtKB/SwissProt ID | O06213 |
NCBI RefSeq | NP_216680.1 |
EMBL-CDS | CCP44941.3 |
UniProtKB Sequence | >tr|O06213|O06213_MYCTU Membrane protein OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=Rv2164c PE=1 SV=1 MRAKREAPKSRSSDRRRRADSPAAATRRTTTNSAPSRRIRSRAGKTSAPGRQARVSRPGP QTSPMLSPFDRPAPAKNTSQAKARAKARKAKAPKLVRPTPMERLAARLTSIDLRPRTLAN KVPFVVLVIGSLGVGLGLTLWLSTDAAERSYQLSNARERTRMLQQHKEALERDVREAASA PALAEAARRQGMIPTRDTAHLVQDPDGNWVVVGTPKPADGVPPPPLNTKLPEDPPPPPKP AAVPLEVPVRVTPGPDDPAPPARSGPEVLVRTPDGTATLGGATHLPTQAGPQLPGPVPIP GAPGPMPAPPLGAVPSPAPAENPVPLQVGAAPPAGLPGPAPVAATPGLSGGSQPMVAPPA PVPANGEQFGPVTAPVPTAPGAPR |
Sequence length | 382 AA |
Subcellular Location | Membrane |
Glycosylation Status | |
Glycosylation Type | O- (Thr) linked |
Experimentally Validated Glycosite(s) in Full Length Protein | T252 |
Glycosite(s) Annotated Protein Sequence | >tr|O06213|O06213_MYCTU Membrane protein OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=Rv2164c PE=1 SV=1 MRAKREAPKSRSSDRRRRADSPAAATRRTTTNSAPSRRIRSRAGKTSAPGRQARVSRPGP QTSPMLSPFDRPAPAKNTSQAKARAKARKAKAPKLVRPTPMERLAARLTSIDLRPRTLAN KVPFVVLVIGSLGVGLGLTLWLSTDAAERSYQLSNARERTRMLQQHKEALERDVREAASA PALAEAARRQGMIPTRDTAHLVQDPDGNWVVVGTPKPADGVPPPPLNTKLPEDPPPPPKP AAVPLEVPVRVT*(252)PGPDDPAPPARSGPEVLVRTPDGTATLGGATHLPTQAGPQLPGPVPIP GAPGPMPAPPLGAVPSPAPAENPVPLQVGAAPPAGLPGPAPVAATPGLSGGSQPMVAPPA PVPANGEQFGPVTAPVPTAPGAPR |
Sequence Around Glycosites (21 AA) | AVPLEVPVRVTPGPDDPAPPA |
Average Amino Acid Composition around Glycosite(s) | _VT(he)PGPDDPAPPAR_ |
Technique(s) used for Glycosylation Detection | LC-MS (HCD) |
Technique(s) used for Glycosylated Residue(s) Detection | HCD |
Glycan Information | |
Glycan Annotation | Hex |
Literature | |
Year of Identification | 2014 |
Year of Identification Month Wise | 2014.1.31 |
Reference | Smith, G.T., Sweredoski, M.J. and Hess, S., 2014. O-linked glycosylation sites profiling in Mycobacterium tuberculosis culture filtrate proteins. Journal of proteomics, 97, pp.296-306. |
Corresponding Author | Sonja Hess |
Contact | Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA |