ProGT33.4 (GtfF)

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ProGT ID ProGT33.4 (GtfF)
Organism Information
Organism NameStreptococcus agalactiae serotype III (strain NEM316)
Domain Bacteria
Classification Phylum : Firmicutes
Class : Bacilli
Orders : Lactobacillales
Family : Streptococcaceae
Genus : Stretococcus
Species : agalactiae
Strain : NEM316
Taxonomic ID (NCBI)211110
Genome Information
Gene BankAL766851.1
EMBLAL766851.1
Gene Information
Gene Namegbs1526 
NCBI Reference SequenceCAD47185
Protein information
Protein NameGtfF 
UniProtKB/ SwissProt IDQ8E476
NCBI Ref SeqWP_001865283.1
UniProtKB Sequence>tr|Q8E476|Q8E476_STRA3 Uncharacterized protein OS=Streptococcus agalactiae serotype III (strain NEM316) GN=gbs1526 PE=4 SV=1 MKNRKAIALAADFGYQEQVKTIIKSICFHNQFIDFYILNDDFPVEWFQMMEYHLSKMDCT ISNTKIFNEEIKHFKFQKPMPYPTYFRYFIPEVIHEDKVLYLDCDMIITSDLTSIFTLDI SKYGVAAVRDDLLEEYDGKEDYFNSGLLLINNIFWREQGISQRLLDYTRENQGALQYHDQ DVLNDVLCDNWLELDETYNYHTGADMLYNLFQQSERQLNRRKDLPKVIHYTATKPWKYLE TSVRWRDIWWEYNRLEWRDIFTRWQVNDGVDVSLKKVLQPIHRAFIFTYSDSIEGIERLA KDLPNWQFHIAAYTQISEKLKQLEMHSNIKLYPLVYRFKLNELVENSDIYLDINHGDADT QVLEQVKKLGKDILSLSTTYHGQGKQFERVTDIIDYLKNERFKEHIRKEYCEK
EMBL CDSCAD47185.1
Sequence length413 AA
String211110.gbs1526.
Glycosylation Information
CAZY FamilyGT8
EC Number (BRENDA)2.4.1.-
Experimental ValidationIn vivo
Additional Information1) Srr1 is important for the virulence of S. agalactiae NEM316.
2) The reactivity of Srr1 toward lectin and the monosaccharide composition analysis of full-length protein showed that Srr1 was mainly modified with GlcNAc and Glc residues, strongly suggesting that HexNAc and Hex should correspond to these two sugars.  
Litrature
Year Of Validation2009 
Reference Mistou, M.Y., Dramsi, S., Brega, S., Poyart, C. and Trieu-Cuot, P., 2009. Molecular dissection of the secA2 locus of group B Streptococcus reveals that glycosylation of the Srr1 LPXTG protein is required for full virulence. Journal of bacteriology, 191(13), pp.4195-4206.

Corresponding AuthorInstitut Pasteur, Biological Unit of Gram-Positive Pathogenic Bacteria, URA CNRS 2172, Paris Cedex 15, France.
Reference Chaze, T., Guillot, A., Valot, B., Langella, O., Chamot-Rooke, J., Di Guilmi, A.M., Trieu-Cuot, P., Dramsi, S. and Mistou, M.Y., 2014. O-Glycosylation of the N-terminal region of the serine-rich adhesin Srr1 of Streptococcus agalactiae explored by mass spectrometry. Molecular & Cellular Proteomics, 13(9), pp.2168-2182.

Corresponding AuthorINRA, MICALIS UMR-1319, 78352 Jouy-en-Josas cedex, France