ProGT42.1 (Alpha-1,6-glucosyltransferase)

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ProGT ID ProGT42.1 (Alpha-1,6-glucosyltransferase)
ProGT Pathway
Organism Information
Organism NameActinobacillus pleuropneumoniae AP76
Domain Bacteria
Classification Phylum : Proteobacteria
Class : Gammaproteobacteria
Orders : Pasteurellales
Family : Pasteurellaceae
Genus : Actinobacillus
Species : pleuropneumoniae
Strain : AP76
Taxonomic ID (NCBI)537457
Protein information
Protein NameAlpha-1,6-glucosyltransferase 
UniProtKB/ SwissProt IDB3H2N1
NCBI Ref SeqWP_005618105.1
UniProtKB Sequence>sp|B3H2N1|GTF_ACTP7 Alpha-1,6-glucosyltransferase OS=Actinobacillus pleuropneumoniae serotype 7 (strain AP76) GN=APP7_1696 PE=1 SV=1 MENNIDLNVYFCFVNRPCTGGDFVNLDHVRTLRKLGINASILLAGNQSEEIVNSFGSLPV VILNEEIEFSSQDIFIVPEVMQVLYDLASKMTVFPRMIMHNQNPFYTGYGFLSAQHINEH RLERIIVPSSYTKYKLQEIGVTKPIDIIHPYIPDYFKPAEKQREVIQIAFSRRKRSAEFD IFKFYFLSLYSHKHSVNFVNIQGLTREEVAKVMSEAAIFISFAERESLGLMTLEAMASGC HVIGFSGYTDIYNNEVIDDSVGDWIGEGEYTLFAQKVCQAIDDFVNGKMNPKIENGLRLI EQRFRIRHFEQEVKRVYGNIFDYDLENSRS
EMBL CDSACE62348.1
Sequence length330 AA
Subcellular LocationCytoplasm
Glycosylation Information
Sugar Donor SpecificityUDP-Glc 
Acceptor Substrate SpecificityGlucose modifed Hexapeptide DANYTK (labeled with TAMRA at N-terminus)
Experimental ValidationIn vitro
Donor SpecificityUDP-Glc
Function in Glycosylation pathway1) It polymerizes the glucose modified product of NGT catalyzed reaction.
Additional Information1) It is a glucose polymerization enzyme which transfers up to six glucose molecules on the previously glucose modified protein. 
Litrature
Year Of Validation2011 
Reference Schwarz, F., Fan, Y.Y., Schubert, M. and Aebi, M., 2011. Cytoplasmic N-glycosyltransferase of Actinobacillus pleuropneumoniae is an inverting enzyme and recognizes the NX (S/T) consensus sequence. Journal of Biological Chemistry, 286(40), pp.35267-35274.

Corresponding AuthorMolecular Biology and Biophysics, Department of Biology, ETH Zürich, 8093 Zürich, Switzerland Inst. of Microbiology, Dept. of Biology, ETH Zürich, Wolfgang-Pauli-Str. 10, 8093 Zürich, Switzerland
Reference Schwarz, F., Fan, Y.Y., Schubert, M. and Aebi, M., 2011. Cytoplasmic N-glycosyltransferase of Actinobacillus pleuropneumoniae is an inverting enzyme and recognizes the NX (S/T) consensus sequence. Journal of Biological Chemistry, 286(40), pp.35267-35274.

Corresponding AuthorMolecular Biology and Biophysics, Department of Biology, ETH Zürich, 8093 Zürich, Switzerland Inst. of Microbiology, Dept. of Biology, ETH Zürich, Wolfgang-Pauli-Str. 10, 8093 Zürich, Switzerland