ProGT139 (YART)
| ProGT ID | ProGT139 (YART) |
| Organism Information | |
| Organism Name | Yersinia mollaretii |
| Clinical Implication | Pathogenic |
| Domain | Bacteria |
| Classification | Phylum : Proteobacteria Class : GammaProteobacteria Orders : Enterobacterales Family : Yersiniaceae Genus : Yersinia Species : mollaretii |
| Taxonomic ID (NCBI) | 349967 |
| Genome Information | |
| Gene Information | |
| Gene Name | yart |
| Protein information | |
| Protein Name | YART |
| Function in Native Organism | It is ADP-ribosyltransferase and transfer ADP-ribosylates Rab5 and Rab31 at Gln79 and Gln64, respectively |
| Additional Information | The glycosylation of Rab5 and Rab31 inhibiting GTP hydrolysis. |
| Glycosyltransferase Information | |
| Glycosylation Type | N- (Gln) linked |
| Mechanism of Glycan Transfer | Sequential |
| Donor Specificity | Nucleotide activated sugars |
| Glycan Information | |
| Method of Glycan Indentification | NanoLC-MS/MS analysis and Western Blotting |
| Experimental_strategies | In vitro |
| Acceptor Subtrate Information | |
| Acceptor Substrate name | Rab5 |
| Acceptor Substrate name | Rab31 |
| Litrature | |
| Year Of Validation | 2020 |
| Reference | Ost, G.S., Wirth, C., Bogdanovi?, X., Kao, W.C., Schorch, B., Aktories, P.J., Papatheodorou, P., Schwan, C., Schlosser, A., Jank, T. and Hunte, C., 2020. Inverse control of Rab proteins by Yersinia ADP-ribosyltransferase and glycosyltransferase related to clostridial glucosylating toxins. Science advances, 6(11), p.eaaz2094. |
| Corresponding Author | Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany |