ProGT139 (YART)
ProGT ID | ProGT139 (YART) |
Organism Information | |
Organism Name | Yersinia mollaretii |
Clinical Implication | Pathogenic |
Domain | Bacteria |
Classification | Phylum : Proteobacteria Class : GammaProteobacteria Orders : Enterobacterales Family : Yersiniaceae Genus : Yersinia Species : mollaretii |
Taxonomic ID (NCBI) | 349967 |
Genome Information | |
Gene Information | |
Gene Name | yart |
Protein information | |
Protein Name | YART |
Function in Native Organism | It is ADP-ribosyltransferase and transfer ADP-ribosylates Rab5 and Rab31 at Gln79 and Gln64, respectively |
Additional Information | The glycosylation of Rab5 and Rab31 inhibiting GTP hydrolysis. |
Glycosyltransferase Information | |
Glycosylation Type | N- (Gln) linked |
Mechanism of Glycan Transfer | Sequential |
Donor Specificity | Nucleotide activated sugars |
Glycan Information | |
Method of Glycan Indentification | NanoLC-MS/MS analysis and Western Blotting |
Experimental_strategies | In vitro |
Acceptor Subtrate Information | |
Acceptor Substrate name | Rab5 |
Acceptor Substrate name | Rab31 |
Litrature | |
Year Of Validation | 2020 |
Reference | Ost, G.S., Wirth, C., Bogdanovi?, X., Kao, W.C., Schorch, B., Aktories, P.J., Papatheodorou, P., Schwan, C., Schlosser, A., Jank, T. and Hunte, C., 2020. Inverse control of Rab proteins by Yersinia ADP-ribosyltransferase and glycosyltransferase related to clostridial glucosylating toxins. Science advances, 6(11), p.eaaz2094. |
Corresponding Author | Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany |