ProGT143 (SvGT)

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ProGT ID ProGT143 (SvGT)
Organism Information
Organism NameStreptomycetes venezulae strain 15439
Clinical ImplicationNon-pathogenic
Classification Phylum : Actinobacteria
Class : Actinomycetia
Orders : Streptomycetales
Family : Streptomyycetaceae
Genus : Streptomyces
Species : venezuelae
Taxonomic ID (NCBI)54571
Genome Information
Gene BankCP013129.1
Gene Information
Gene NameSvGT
Protein information
Protein NameSvGT 
NCBI Ref SeqALO08693.1
Function in Native Organism SvGT define the distinct donor specificity, acceptor specificity, regioselectivity, chemoselectivity, and Y(G/A/K/Q/E??G)(C/S/T?Y/N)(G/A?P/Q)G as the minimum acceptor sequon of SvGT. Although UDP-GlcNAc served as the donor in the cellular milieu, SvGT could also utilize UDP-Glc and UDP-GalNAc as donors in vitro
Additional InformationAlso used as glycoengineering tool for modification of neo glycocin
Glycosyltransferase Information
Glycosylation TypeS- (Cys) and O- (Ser/Thr) linked 
CAZY FamilyGT2
Mechanism of Glycan TransferSequential
Donor TypeUDP-GlcNAc, UDP-Glc, UDP-GalNAc
Donor SpecificityNucleotide activated sugars
Glycan Information
Glycan transferredMonosaccharide (GlcNAc, Glc, GalNAc) 
Method of Glycan Indentificationmass spectrometry and western blotting
Experimental_strategiesIn vivo and In vitro 
Acceptor Subtrate Information
Acceptor Substrate name SvC
ProGPdb ID ProGP1215 (SvC)
Year Of Validation2021 
Reference Sharma, Y., Ahlawat, S. and Rao, A., 2021. Biochemical characterization of an inverting S/O-HexNAc-transferase and evidence of S-linked glycosylation in Actinobacteria. Glycobiology.

Corresponding Author2 CSIR-Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India