ProGT74 (FilmQ)
| ProGT ID | ProGT74 (FilmQ) |
| Organism Information | |
| Organism Name | Burkholderia cenocepacia K56-2 |
| Clinical Implication | Pathogenic |
| Domain | Bacteria |
| Classification | Phylum : Proteobacteria Class : BetaProteobacteria Orders : Burkholderiales Family : Burkholderiaceae Genus : Burkholderia Species : cenocepacia Strain : K56-2 |
| Taxonomic ID (NCBI) | 216591 |
| Genome Information | |
| Gene Bank | AM747720 |
| EMBL | AM747720 |
| Gene Information | |
| Gene Name | BCAL0111 |
| NCBI Gene ID | 6930761 |
| NCBI Reference Sequence | NC_011000.1. |
| Protein information | |
| Protein Name | FilmQ |
| UniProtKB/ SwissProt ID | B4EDI5 |
| NCBI Ref Seq | WP_006484115.1 |
| UniProtKB Sequence | >tr|B4EDI5|B4EDI5_BURCJ Putative TPR repeat protein OS=Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) GN=BCAL0111 PE=4 SV=1 MFSTELPATAALTPEQQLAQDIALVMENALERQRSGAFDDARALYEAILDAVPAHGDAHY NLAVLMVDTGQATDAVPHFEAAIGANPDNGYYWVSYIHALHRTGQTAAAWIAVEIAQQRG VHGPALDGLIAQLASPEVVLATAAVAPSGIDAAIVLETATGHAGRSDSGKPVRRPNQTLL QKHAALFDKNKHAEATALARQLVADYPQDGACWRALSASLHREGRFAEMIEAGFRTIELL PDELLVRMLLADTLRVMNRLEEADEQCTRLIQLQPDHPEAFRIRGLVLFALRRMDEAIAA CRRAVELAPGAAAPCGTLGFVLLEQGATQEAMGWLKRSIEINPTDSVTHSSMLFCITHIS DFDPQALITEHRKFGERYGNHKRKRAAVFSNSRDPARKLQVGFVSGDLFSHAVASYAVPV IEHLAADPGIAMHFYHNHFEEDHVSERFKAHATTWRTVAGMSDTAFLERVRNDRIDIVID LSGHTGRNRLVALAQRAAPVQASWIGYPATTGLAAMDYYLADRFLAPHGQFEDQFVERIV RLPAIASFMPPVNCPPVNVLPALHNGYTTYGSFNRLNKLSSHVIAVWARVLHADPTARMA LGAIGNEGDQQTLTEWFVAAGIDASRLSFHRRSNIPVYMQQHHGVDLCLDTFPYTGSTTT LNGLWMGVPTLTIPGSTMAGRGSASWLQHVGCDAYIANDEDDFVAKALALSSDTTTLQAL RAGLRARCSASAAFRPDVVAAGLSSALRTMWVRWCANEPVTAFDTPLFDDTATAPAAAEA |
| EMBL CDS | CAR50419.1 |
| Sequence length | 780 AA |
| String | 216591.BCAL0111 |
| Additional Information | 1) flmQ encodes a glycosyltransferase, which is essential for FliC glycosylation and this glycosylation of FliC reduces TLR5-mediated signal transduction and gene expression in the host. |
| Glycosyltransferase Information | |
| Glycosylation Type | O- (Ser/Thr) linked |
| CAZY Family | GT41 |
| EC Number (BRENDA) | 2.4.1.B62. 13625. |
| Mechanism of Glycan Transfer | Sequential |
| Glycan Information | |
| Glycan transferred | 4,6-dideoxy-4-(3-hydroxybutanoylamino)-D-glucose |
| Method of Glycan Indentification | LC-MS-MS, GC/MS |
| Experimental_strategies | In vivo |
| Acceptor Subtrate Information | |
| Acceptor Substrate name | FliC |
| ProGPdb ID | ProGP494 |
| Litrature | |
| Year Of Validation | 2014 |
| Reference | Hanuszkiewicz, A., Pittock, P., Humphries, F., Moll, H., Rosales, A.R., Molinaro, A., Moynagh, P.N., Lajoie, G.A. and Valvano, M.A., 2014. Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune responses. Journal of Biological Chemistry, 289(27), pp.19231-19244. |
| Corresponding Author | 1 Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast BT9 7AE, Ireland, United Kingdom. 2 Department of Microbiology and Immunology, University of Western Ontario, London, Ontario N6A 5C1, Canada. |